I'm glad to see that there's somebody out there reading these things.
My main reason for doing mutlisite instead of separate wordpress installations is ease of management from one dashboard. I'm only using it for several subdomains of my own (not making it available to others).
I didn't have any problem installing multisite or using it. I found it quite easy. Although, while I am not a "professional," I am not really a Wordpress Beginner either. I've been using and tweaking it for years.
And I think I am almost "professional" in my ability to cut and paste code.
Although, I would agree with the idea that someone who isn't already really comfortable using Wordpress wouldn't want to do this, because using Multisite does involve manually adding some code to your files, which I did via ftp.
On a side note: Now that I have walked through this process, I wouldn't ask the original question the same way.
I think most support types take "support" to mean "will you help me set this up and solve problems if it breaks." Whereas, I only meant "will the server software and various policies support this technically."
I now know that the answer to that question is "yes, accept for the wildcard redirect."
So... It meets my needs easily.