You can use front page to up-load your site, or you can use filezilla - it makes little difference in the end. With front page extensions turned off, you'll not be using the 'live' feature, but just upload your site.
You'll want to connect to yourDomain.com at the ftp address, and you'll need to use the user/pass associated with the domain. You'll also need to place the files in the directory named after yourDomain.com. I can't remember off hand how you set this in front page, but I think it give you a place to specify a sub-directory for publishing.
I believe if you search a bit you can find more detailed instructions on setting up Front page, You'll probably have to weed through some non-relative discussions, but you should be able to find detailed setup info.