PHP.ini changes not taken into consideration?

I installed my own php.ini on my VPS with

On my phpinfo() I see “Loaded Configuration file is /home/mydomain/cgi-bin/php.ini” which corresponds to the php.ini file I edited.

Unfortunately the made changes do not appear! I set memory_limit to 256M instead of 90M, but I still see 90M on my phpinfo().

Any idea on how I could correctly apply changes? Many thanks in advance.