The tables in the database are read only so they will not get deleted or altered until the host is removed.
This is what the manual has to say:-
"In effect, we have a database named INFORMATION_SCHEMA, although the server does not create a database directory with that name. It is possible to select INFORMATION_SCHEMA as the default database with a USE statement, but it is possible only to read the contents of tables. You cannot insert into them, update them, or delete from them."
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