Autoresponders for specific sender addresses

I’m trying to figure out if there is any way to specify autoresponders for specific SENDER addresses. For example, when people send mail to my main account, I would like about 3 of them to get an autoresponse that doesn’t go to anyone else.

Is this possible?

Do you have the old-style Maildir account? If so, then you can conveniently create some procmail filtering that will handle this. If not, you can jump through some hoops to make this happen:

I’m more on the lazy side, so I’d create some rules in my mail client at home, but that’d only run when I’m logged in and have my mail app running.