On weekends yes. If the automated system throws you out for a manual approval then you have to wait until normal business hours monday-friday before anything will happen.
If you take a gander through the forum, it's perhaps the only single issue that gathers posts weekly, and without missing a week.
It was even pointed out last week that one of the messages a new customer sees is that the manual process should take less than 24 hours, but it seems like it could take 60 or more hours if your timing is the worst.
It would seem this problem should be really easy to solve too.